› 2r4b

X-ray diffraction
2.4Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172255 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ERBB4 intracellular domain Chains: A, B
Molecule details ›
Chains: A, B
Length: 321 amino acids
Theoretical weight: 36.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15303 (Residues: 690-999; Coverage: 24%)
Gene names: ERBB4, HER4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GW7 2 x GW7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P43
Unit cell:
a: 63.872Å b: 63.872Å c: 163.607Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.263
Expression system: Spodoptera frugiperda

Quick links

Citations

13 review citations

The ErbB/HER family of protein-tyrosine kinases and cancer.
Roskoski R. (2014)
12 more

14 mentions without citation

Computational algorithms for in silico profiling of activating mutations in cancer.
Jordan et al. (2019)
13 more