› 2r83

X-ray diffraction
2.7Å resolution

Crystal structure analysis of human synaptotagmin 1 C2A-C2B

Released:
DOI: 10.2210/pdb2r83/pdb
PDB entry 2r83 coloured by chain, front view.
PDB entry 2r83 coloured by chain, side view.
PDB entry 2r83 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association.
Fuson KL, Montes M, Robert JJ, Sutton RB
Biochemistry 46 13041-8 (2007)
PMID: 17956130

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149307 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptotagmin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 284 amino acids
Theoretical weight: 32.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21579 (Residues: 141-422; Coverage: 67%)
Gene names: SVP65, SYT, SYT1
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand CL 8 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 82.372Å b: 86.31Å c: 147.186Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.253
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Molecular machines governing exocytosis of synaptic vesicles.
Jahn et al. (2012)
6 more

21 mentions without citation

Three-dimensional molecular modeling with single molecule FRET.
Brunger et al. (2011)
20 more