› 2rd6

X-ray diffraction
2.3Å resolution

PARP complexed with A861695

Released:
DOI: 10.2210/pdb2rd6/pdb
PDB entry 2rd6 coloured by chain, front view.
PDB entry 2rd6 coloured by chain, side view.
PDB entry 2rd6 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Park CH

Function and Biology Details

Reaction catalysed: 
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase 1, processed C-terminus Chain: A
Molecule details ›
Chain: A
Length: 350 amino acids
Theoretical weight: 39.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09874 (Residues: 662-1011; Coverage: 35%)
Gene names: ADPRT, PARP1, PPOL
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 78P 1 x 78P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P321
Unit cell:
a: 94.537Å b: 94.537Å c: 68.502Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.243 0.228 0.308
Expression system: Escherichia coli

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