› 2rg8

X-ray diffraction
1.8Å resolution

Crystal Structure of Programmed for Cell Death 4 Middle MA3 domain

Released:
DOI: 10.2210/pdb2rg8/pdb
PDB entry 2rg8 coloured by chain, front view.
PDB entry 2rg8 coloured by chain, side view.
PDB entry 2rg8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.
Suzuki C, Garces RG, Edmonds KA, Hiller S, Hyberts SG, Marintchev A, Wagner G
Proc Natl Acad Sci U S A 105 3274-9 (2008)
PMID: 18296639

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176086 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q53EL6 (Residues: 157-320; Coverage: 35%)
Gene names: H731, PDCD4
Sequence domains: MA3 domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand NA 3 x NA
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 37.68Å b: 70.06Å c: 110.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

29 review citations

miR-21: a small multi-faceted RNA.
Krichevsky et al. (2009)
28 more

4 mentions without citation

PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.
Suzuki et al. (2008)
3 more