› 2rjl

X-ray diffraction
2.05Å resolution

Crystal structure of human TL1A extracellular domain C95S/C135S mutant

Released:
DOI: 10.2210/pdb2rjl/pdb
PDB entry 2rjl coloured by chain, front view.
PDB entry 2rjl coloured by chain, side view.
PDB entry 2rjl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biochemical and structural characterization of the human TL1A ectodomain.
Zhan C, Yan Q, Patskovsky Y, Li Z, Toro R, Meyer A, Cheng H, Brenowitz M, Nathenson SG, Almo SC
Biochemistry 48 7636-45 (2009)
PMID: 19522538

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 15, secreted form Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 20.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95150 (Residues: 72-251; Coverage: 72%)
Gene names: TL1, TNFSF15, VEGI
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P4132
Unit cell:
a: 117.584Å b: 117.584Å c: 117.584Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.244
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Structural principles of tumor necrosis factor superfamily signaling.
Vanamee et al. (2018)
7 more

2 mentions without citation

Biochemical and structural characterization of the human TL1A ectodomain.
Zhan et al. (2009)
1 more