› 2rjp

X-ray diffraction
2.8Å resolution

Function and Biology Details

Reaction catalysed: 
Glutamyl endopeptidase. Bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A disintegrin and metalloproteinase with thrombospondin motifs 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 316 amino acids
Theoretical weight: 34.22 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O75173 (Residues: 213-520; Coverage: 39%)
Gene names: ADAMTS4, KIAA0688, UNQ769/PRO1563
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 4 x ZN
Ligand CA 12 x CA
Ligand 886 4 x 886
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 82.566Å b: 82.618Å c: 99.326Å
α: 90° β: 90.63° γ: 90°
R-values:
R R work R free
0.209 0.206 0.267
Expression system: Cricetulus griseus

Quick links

Citations

14 review citations

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family.
Kelwick et al. (2015)
13 more

13 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
12 more