› 2rmn

Solution NMR

The solution structure of the p63 DNA-binding domain

Released:
DOI: 10.2210/pdb2rmn/pdb
PDB entry 2rmn coloured by chain, ensemble of 21 models, front view.
PDB entry 2rmn coloured by chain, ensemble of 21 models, side view.
PDB entry 2rmn coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and binding specificity of the p63 DNA binding domain.
Enthart A, Klein C, Dehner A, Coles M, Gemmecker G, Kessler H, Hagn F
Sci Rep 6 26707 (2016)
PMID: 27225672

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190571 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein 63 Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 25.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H3D4 (Residues: 153-388; Coverage: 34%)
Gene names: KET, P63, P73H, P73L, TP63, TP73L
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy.
Timofeev et al. (2021)
4 more

11 mentions without citation

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.
Melino G. (2011)
10 more