› 2ror

Solution NMR

Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76

Released:
DOI: 10.2210/pdb2ror/pdb
PDB entry 2ror coloured by chain, ensemble of 20 models, front view.
PDB entry 2ror coloured by chain, ensemble of 20 models, side view.
PDB entry 2ror coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Tanaka M, Kasai T, Koshiba S, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147392 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proto-oncogene vav Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.5 KDa
Source organism: Homo sapiens
Expression system: CELL-FREE SYNTHESIS
UniProt:
  • Canonical: P15498 (Residues: 629-775; Coverage: 15%)
Gene names: VAV, VAV1
Sequence domains: SH2 domain
Structure domains: SH2 domain
Lymphocyte cytosolic protein 2 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13094 (Residues: 122-136; Coverage: 3%)
Gene name: LCP2

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

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