› 2rpc

Solution NMR

Solution structure of the tandem zf-C2H2 domains from the human zinc finger protein ZIC 3

Released:
DOI: 10.2210/pdb2rpc/pdb
PDB entry 2rpc coloured by chain, ensemble of 20 models, front view.
PDB entry 2rpc coloured by chain, ensemble of 20 models, side view.
PDB entry 2rpc coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain.
Hatayama M, Tomizawa T, Sakai-Kato K, Bouvagnet P, Kose S, Imamoto N, Yokoyama S, Utsunomiya-Tate N, Mikoshiba K, Kigawa T, Aruga J
Hum Mol Genet 17 3459-73 (2008)
PMID: 18716025

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129986 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger protein ZIC 3 Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 17.6 KDa
Source organism: Homo sapiens
Expression system: cell free system
UniProt:
  • Canonical: O60481 (Residues: 245-386; Coverage: 30%)
Gene names: ZIC3, ZNF203
Sequence domains:
Structure domains: Classic Zinc Finger

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: cell free system

Quick links

Citations

8 review citations

Diversification of importin-α isoforms in cellular trafficking and disease states.
Pumroy et al. (2015)
7 more

3 mentions without citation

Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain.
Hatayama et al. (2008)
2 more