› 2rqr

Solution NMR

The solution structure of human DOCK2 SH3 domain - ELMO1 peptide chimera complex

Released:
DOI: 10.2210/pdb2rqr/pdb
PDB entry 2rqr coloured by chain, ensemble of 20 models, front view.
PDB entry 2rqr coloured by chain, ensemble of 20 models, side view.
PDB entry 2rqr coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S
Proc Natl Acad Sci U S A 109 3305-10 (2012)
PMID: 22331897

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dedicator of cytokinesis protein 2; Engulfment and cell motility protein 1 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 12.64 KDa
Source organism: Homo sapiens
Expression system: Cell-free synthesis
UniProt:
  • Canonical: Q92556 (Residues: 697-722; Coverage: 4%)
  • Canonical: Q92608 (Residues: 8-70; Coverage: 3%)
Gene names: DOCK2, ELMO1, KIAA0209, KIAA0281
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression system: Cell-free synthesis

Quick links

Citations

14 review citations

Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils et al. (2013)
13 more

2 mentions without citation

RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors.
Thompson et al. (2021)
1 more