› 2rqz

Solution NMR

Structure of sugar modified epidermal growth factor-like repeat 12 of mouse Notch-1 receptor

Released:
DOI: 10.2210/pdb2rqz/pdb
PDB entry 2rqz coloured by chain, ensemble of 20 models, front view.
PDB entry 2rqz coloured by chain, ensemble of 20 models, side view.
PDB entry 2rqz coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Chemical synthesis, folding, and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor.
Hiruma-Shimizu K, Hosoguchi K, Liu Y, Fujitani N, Ohta T, Hinou H, Matsushita T, Shimizu H, Feizi T, Nishimura S
J Am Chem Soc 132 14857-65 (2010)
PMID: 20883017

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169617 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neurogenic locus notch homolog protein 1 Chain: A
Molecule details ›
Chain: A
Length: 38 amino acids
Theoretical weight: 4.22 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q01705 (Residues: 452-489; Coverage: 2%)
Gene names: Motch, Notch1
Sequence domains: Human growth factor-like EGF

Ligands and Environments

Carbohydrate polymer : NEW Components: FUC, NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

6 review citations

Notch receptor-ligand binding and activation: insights from molecular studies.
Chillakuri et al. (2012)
5 more

1 mention without citation

O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.
Rana et al. (2011)