› 2rr3

Solution NMR

Solution structure of the complex between human VAP-A MSP domain and human OSBP FFAT motif

Released:
DOI: 10.2210/pdb2rr3/pdb
PDB entry 2rr3 coloured by chain, ensemble of 20 models, front view.
PDB entry 2rr3 coloured by chain, ensemble of 20 models, side view.
PDB entry 2rr3 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies.
Furuita K, Jee J, Fukada H, Mishima M, Kojima C
J Biol Chem 285 12961-70 (2010)
PMID: 20178991

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149511 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Vesicle-associated membrane protein-associated protein A Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 14.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P0L0 (Residues: 11-135; Coverage: 50%)
Gene names: VAP33, VAPA
Sequence domains: MSP (Major sperm protein) domain
Structure domains: Immunoglobulins
Oxysterol-binding protein 1 Chain: B
Molecule details ›
Chain: B
Length: 47 amino acids
Theoretical weight: 5.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22059 (Residues: 346-379; Coverage: 4%)
Gene names: OSBP, OSBP1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Applications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010.
Ghai et al. (2012)
9 more

4 mentions without citation

Invisible leashes: The tethering VAPs from infectious diseases to neurodegeneration.
Dudás et al. (2021)
3 more