› 2rs9

Solution NMR

Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide

Released:
DOI: 10.2210/pdb2rs9/pdb
PDB entry 2rs9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2rs9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2rs9 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Qin X, Nagashima T, Umehara T, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157221 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone H4 Chain: A
Molecule details ›
Chain: A
Length: 10 amino acids
Theoretical weight: 960 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62805 (Residues: 2-11; Coverage: 10%)
Gene names: H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4
Peregrin Chain: B
Molecule details ›
Chain: B
Length: 121 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: CELL-FREE SYNTHESIS
UniProt:
  • Canonical: P55201 (Residues: 633-740; Coverage: 9%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: CELL-FREE SYNTHESIS

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