› 2rsq

Solution NMR

Copper(I) loaded form of the first domain of the human copper chaperone for SOD1, CCS

Released:
DOI: 10.2210/pdb2rsq/pdb
PDB entry 2rsq coloured by chain, ensemble of 20 models, front view.
PDB entry 2rsq coloured by chain, ensemble of 20 models, side view.
PDB entry 2rsq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Banci L, Bertini I, Cantini F, Kozyreva T, Rubino JT

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127021 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Copper chaperone for superoxide dismutase Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 9.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14618 (Residues: 1-85; Coverage: 31%)
Gene name: CCS
Sequence domains: Heavy-metal-associated domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

1 bound ligand:
Ligand CU1 1 x CU1
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: Escherichia coli

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