› 2shp

X-ray diffraction
2Å resolution

TYROSINE PHOSPHATASE SHP-2

Released:
DOI: 10.2210/pdb2shp/pdb
PDB entry 2shp coloured by chain, front view.
PDB entry 2shp coloured by chain, side view.
PDB entry 2shp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the tyrosine phosphatase SHP-2.
Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE
Cell 92 441-50 (1998)
PMID: 9491886

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170287 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 525 amino acids
Theoretical weight: 60.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 1-525; Coverage: 89%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CAT 2 x CAT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 45.9Å b: 214.5Å c: 55.7Å
α: 90° β: 96.3° γ: 90°
R-values:
R R work R free
0.199 0.199 0.27
Expression system: Escherichia coli

Quick links

Citations

135 review citations

Principles of interleukin (IL)-6-type cytokine signalling and its regulation.
Heinrich et al. (2003)
134 more

64 mentions without citation

Targeting protein tyrosine phosphatases for anticancer drug discovery.
Scott et al. (2010)
63 more