› 2tmp

Solution NMR

N-TERMINAL DOMAIN OF TISSUE INHIBITOR OF METALLOPROTEINASE-2 (N-TIMP-2), NMR, 49 STRUCTURES

Released:
DOI: 10.2210/pdb2tmp/pdb
PDB entry 2tmp coloured by chain, ensemble of 49 models, front view.
PDB entry 2tmp coloured by chain, ensemble of 49 models, side view.
PDB entry 2tmp coloured by chain, ensemble of 49 models, top view.
Source organism: Homo sapiens
Primary publication:
High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3.
Muskett FW, Frenkiel TA, Feeney J, Freedman RB, Carr MD, Williamson RA
J Biol Chem 273 21736-43 (1998)
PMID: 9705310

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147586 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metalloproteinase inhibitor 2 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16035 (Residues: 27-153; Coverage: 66%)
Gene name: TIMP2
Sequence domains: Tissue inhibitor of metalloproteinase
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING USING TORSION ANGLE DYNAMICS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Matrix metalloproteinases.
Nagase et al. (1999)
6 more

4 mentions without citation

Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families.
Thangudu et al. (2008)
3 more