› 2uv6

X-ray diffraction
2Å resolution

Crystal Structure of a CBS domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP

Released:
DOI: 10.2210/pdb2uv6/pdb
PDB entry 2uv6 coloured by chain, front view.
PDB entry 2uv6 coloured by chain, side view.
PDB entry 2uv6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.
Day P, Sharff A, Parra L, Cleasby A, Williams M, Hörer S, Nar H, Redemann N, Tickle I, Yon J
Acta Crystallogr D Biol Crystallogr 63 587-96 (2007)
PMID: 17452784

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157059 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5'-AMP-activated protein kinase subunit gamma-1 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54619 (Residues: 182-325; Coverage: 44%)
Gene name: PRKAG1
Sequence domains: CBS domain
Structure domains: CBS-domain

Ligands and Environments

1 bound ligand:
Ligand AMP 1 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 66.092Å b: 43.775Å c: 55.786Å
α: 90° β: 119.04° γ: 90°
R-values:
R R work R free
0.176 0.172 0.247
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Hardie DG. (2007)
11 more

5 mentions without citation

Agonist activation of a nicotinic acetylcholine receptor.
Auerbach A. (2015)
4 more