› 2v17

X-ray diffraction
1.65Å resolution

Structure of the complex of antibody MN423 with a fragment of tau protein

Released:
DOI: 10.2210/pdb2v17/pdb
PDB entry 2v17 coloured by chain, front view.
PDB entry 2v17 coloured by chain, side view.
PDB entry 2v17 coloured by chain, top view.
Source organisms:
Primary publication:
X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease.
Sevcik J, Skrabana R, Dvorsky R, Csokova N, Iqbal K, Novak M
FEBS Lett 581 5872-8 (2007)
PMID: 18061582

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211606 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
PEPTIDE FRAGMENT Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 630 Da
Source organism: Homo sapiens
MONOCLONAL ANTIBODY FAB FRAGMENT MN423 Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.5 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
MONOCLONAL ANTIBODY FAB FRAGMENT MN423 Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.78 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P21
Unit cell:
a: 71.541Å b: 36.808Å c: 85.543Å
α: 90° β: 113.93° γ: 90°
R-values:
R R work R free
0.16 0.156 0.218

Quick links

Citations

1 review citation

New age of neuroproteomics in Alzheimer's disease research.
Kovacech et al. (2009)
5 other articles

6 mentions without citation

Conformational selection in amyloid-based immunotherapy: Survey of crystal structures of antibody-amyloid complexes.
Ma et al. (2016)
5 more