Function and Biology Details
Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Phosphatidylinositol 3-kinase alpha (preferred)
PDBe Complex ID:
PDB-CPX-151132 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.82 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
Sequence domains: PI3-kinase family, p85-binding domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Length: 108 amino acids
Theoretical weight: 12.82 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
- Canonical:
P32871 (Residues: 1-108; Coverage: 10%)
Sequence domains: PI3-kinase family, p85-binding domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Phosphatidylinositol 3-kinase regulatory subunit alpha
Molecule details ›
Chain: B
Length: 170 amino acids
Theoretical weight: 21.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Structure domains: Helix Hairpins
Length: 170 amino acids
Theoretical weight: 21.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P27986 (Residues: 431-600; Coverage: 24%)
Sequence domains: Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Structure domains: Helix Hairpins
