› 2v24

X-ray diffraction
2.2Å resolution

Structure of the human SPRY domain-containing SOCS box protein SSB-4

Released:
DOI: 10.2210/pdb2v24/pdb
PDB entry 2v24 coloured by chain, front view.
PDB entry 2v24 coloured by chain, side view.
PDB entry 2v24 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
Filippakopoulos P, Low A, Sharpe TD, Uppenberg J, Yao S, Kuang Z, Savitsky P, Lewis RS, Nicholson SE, Norton RS, Bullock AN
J Mol Biol 401 389-402 (2010)
PMID: 20561531

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188346 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SPRY domain-containing SOCS box protein 4 Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 22.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96A44 (Residues: 28-233; Coverage: 76%)
Gene names: SPSB4, SSB4
Sequence domains: SPRY domain

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 104.22Å b: 104.22Å c: 40.78Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.209 0.26
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Applications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010.
Ghai et al. (2012)
3 more

3 mentions without citation

Structural insight into HIV-1 capsid recognition by rhesus TRIM5α.
Yang et al. (2012)
2 more