› 2v5o

X-ray diffraction
2.91Å resolution

STRUCTURE OF HUMAN IGF2R DOMAINS 11-14

Released:
DOI: 10.2210/pdb2v5o/pdb
PDB entry 2v5o coloured by chain, front view.
PDB entry 2v5o coloured by chain, side view.
PDB entry 2v5o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and functional analysis of the IGF-II/IGF2R interaction.
Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY
EMBO J 27 265-76 (2008)
PMID: 18046459

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cation-independent mannose-6-phosphate receptor Chain: A
Molecule details ›
Chain: A
Length: 627 amino acids
Theoretical weight: 69.33 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P11717 (Residues: 1508-2128; Coverage: 25%)
Gene names: IGF2R, MPRI
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: C2
Unit cell:
a: 138.554Å b: 69.247Å c: 98.012Å
α: 90° β: 103.25° γ: 90°
R-values:
R R work R free
0.259 0.257 0.304
Expression system: Cricetulus griseus

Quick links

Citations

16 review citations

Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.
Brown et al. (2009)
15 more

6 mentions without citation

Structure and functional analysis of the IGF-II/IGF2R interaction.
Brown et al. (2008)
5 more