› 2v7c

X-ray diffraction
2.4Å resolution

Crystal Structure of Rev-Erb beta

Released:
DOI: 10.2210/pdb2v7c/pdb
PDB entry 2v7c coloured by chain, front view.
PDB entry 2v7c coloured by chain, side view.
PDB entry 2v7c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta.
Woo EJ, Jeong DG, Lim MY, Jun Kim S, Kim KJ, Yoon SM, Park BC, Ryu SE
J Mol Biol 373 735-44 (2007)
PMID: 17870090

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172135 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 1 group D member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 194 amino acids
Theoretical weight: 22.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14995 (Residues: 386-579; Coverage: 34%)
Gene name: NR1D2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6C1
Spacegroup: P41212
Unit cell:
a: 71.677Å b: 71.677Å c: 145.566Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.28
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.
Huang et al. (2010)
10 more

1 mention without citation

The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.
Pardee et al. (2009)