› 2vc8

X-ray diffraction
1.31Å resolution

Crystal structure of the LSm domain of human EDC3 (enhancer of decapping 3)

Released:
DOI: 10.2210/pdb2vc8/pdb
PDB entry 2vc8 coloured by chain, front view.
PDB entry 2vc8 coloured by chain, side view.
PDB entry 2vc8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.
Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O
Mol Cell Biol 27 8600-11 (2007)
PMID: 17923697

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188493 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enhancer of mRNA-decapping protein 3 Chain: A
Molecule details ›
Chain: A
Length: 84 amino acids
Theoretical weight: 8.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96F86 (Residues: 1-82; Coverage: 16%)
Gene names: EDC3, LSM16, PP844, YJDC, YJEFN2
Sequence domains: Scd6-like Sm domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P3221
Unit cell:
a: 37.3Å b: 37.3Å c: 79.209Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.196 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

17 review citations

The control of mRNA decapping and P-body formation.
Franks et al. (2008)
16 more

9 mentions without citation

How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms.
Corley et al. (2020)
8 more