› 2vgq

X-ray diffraction
2.1Å resolution

Crystal Structure of Human IPS-1 CARD

Released:
DOI: 10.2210/pdb2vgq/pdb
PDB entry 2vgq coloured by chain, front view.
PDB entry 2vgq coloured by chain, side view.
PDB entry 2vgq coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain.
Potter JA, Randall RE, Taylor GL
BMC Struct Biol 8 11 (2008)
PMID: 18307765

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142582 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Maltose/maltodextrin-binding periplasmic protein; Mitochondrial antiviral-signaling protein Chain: A
Molecule details ›
Chain: A
Length: 477 amino acids
Theoretical weight: 53.41 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-388; Coverage: 98%)
  • Canonical: Q7Z434 (Residues: 3-93; Coverage: 17%)
Gene names: IPS1, JW3994, KIAA1271, MAVS, VISA, b4034, malE
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P41212
Unit cell:
a: 99.26Å b: 99.26Å c: 163.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.22
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Immune signaling by RIG-I-like receptors.
Loo et al. (2011)
18 more

22 mentions without citation

Parts, assembly and operation of the RIG-I family of motors.
Rawling et al. (2014)
21 more