› 2vi6

X-ray diffraction
2.6Å resolution

Crystal Structure of the Nanog Homeodomain

Released:
DOI: 10.2210/pdb2vi6/pdb
PDB entry 2vi6 coloured by chain, front view.
PDB entry 2vi6 coloured by chain, side view.
PDB entry 2vi6 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.
Jauch R, Ng CK, Saikatendu KS, Stevens RC, Kolatkar PR
J Mol Biol 376 758-70 (2008)
PMID: 18177668

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homeobox protein NANOG Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 62 amino acids
Theoretical weight: 7.6 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q80Z64 (Residues: 96-155; Coverage: 20%)
Gene names: Ecat4, Enk, Nanog
Sequence domains: Homeodomain
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 105.318Å b: 114.771Å c: 62.771Å
α: 90° β: 98.68° γ: 90°
R-values:
R R work R free
0.223 0.221 0.265
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The transcriptional foundation of pluripotency.
Chambers et al. (2009)
4 more

6 mentions without citation

Fast and accurate multivariate Gaussian modeling of protein families: predicting residue contacts and protein-interaction partners.
Baldassi et al. (2014)
5 more