› 2vll

X-ray diffraction
1.6Å resolution

The Structural Dynamics and Energetics of an Immunodominant T-cell Receptor are Programmed by its Vbeta Domain

Released:
DOI: 10.2210/pdb2vll/pdb
PDB entry 2vll coloured by chain, front view.
PDB entry 2vll coloured by chain, side view.
PDB entry 2vll coloured by chain, top view.
Source organisms:
Primary publication:
The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.
Ishizuka J, Stewart-Jones GB, van der Merwe A, Bell JI, McMichael AJ, Jones EY
Immunity 28 171-82 (2008)
PMID: 18275829

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137063 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Matrix protein 1 Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 966 Da
Source organism: unidentified influenza virus
Expression system: Not provided
UniProt:
  • Canonical: P03485 (Residues: 58-66; Coverage: 4%)
Gene name: M

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P1
Unit cell:
a: 49.615Å b: 62.335Å c: 74.521Å
α: 82.33° β: 76.44° γ: 78.42°
R-values:
R R work R free
0.194 0.192 0.242
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

15 review citations

T cell antigen receptor recognition of antigen-presenting molecules.
Rossjohn et al. (2015)
14 more

6 mentions without citation

Understanding the Role of HLA Class I Molecules in the Immune Response to Influenza Infection and Rational Design of a Peptide-Based Vaccine.
Muraduzzaman et al. (2022)
5 more