› 2voo

X-ray diffraction
1.8Å resolution

Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU

Released:
DOI: 10.2210/pdb2voo/pdb
PDB entry 2voo coloured by chain, front view.
PDB entry 2voo coloured by chain, side view.
PDB entry 2voo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein.
Kotik-Kogan O, Valentine ER, Sanfelice D, Conte MR, Curry S
Structure 16 852-62 (2008)
PMID: 18547518

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138684 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Lupus La protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 22.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05455 (Residues: 4-194; Coverage: 47%)
Gene name: SSB
Sequence domains:
Structure domains:
5'-R(*UP*UP*UP*UP*UP*UP*UP)-3' Chains: C, D
Molecule details ›
Chains: C, D
Length: 7 nucleotides
Theoretical weight: 2.1 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21212
Unit cell:
a: 98.309Å b: 114.586Å c: 37.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.25 0.279
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

11 review citations

Lessons from the crystallographic analysis of small molecule binding to human serum albumin.
Curry S. (2009)
10 more

6 mentions without citation

Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein.
Kotik-Kogan et al. (2008)
5 more