› 2vq1

X-ray diffraction
2.5Å resolution

anti trimeric Lewis X Fab54-5C10-A

Released:
DOI: 10.2210/pdb2vq1/pdb
PDB entry 2vq1 coloured by chain, front view.
PDB entry 2vq1 coloured by chain, side view.
PDB entry 2vq1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Characterization of a diagnostic Fab fragment binding trimeric Lewis X.
de Geus DC, van Roon AM, Thomassen EA, Hokke CH, Deelder AM, Abrahams JP
Proteins 76 439-47 (2009)
PMID: 19173313

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213183 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IGKV1-117 PROTEIN Chains: A, E
Molecule details ›
Chains: A, E
Length: 217 amino acids
Theoretical weight: 23.96 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
ANTI-HUMAN FC GAMMA RECEPTOR III 3G8 GAMMA HEAVY CHAIN VARIABLE REGION Chains: B, F
Molecule details ›
Chains: B, F
Length: 218 amino acids
Theoretical weight: 23.43 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand GLY 8 x GLY
Ligand GOL 3 x GOL
Ligand AZI 1 x AZI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 51.384Å b: 161.015Å c: 53.48Å
α: 90° β: 103.07° γ: 90°
R-values:
R R work R free
0.206 0.203 0.26

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Citations

1 review citation

Antibody recognition of aberrant glycosylation on the surface of cancer cells.
Soliman et al. (2017)
1 other article