› 2vr3

X-ray diffraction
1.95Å resolution

Structural and Biochemical Characterization of Fibrinogen binding to ClfA from Staphylocccus aureus

Released:
DOI: 10.2210/pdb2vr3/pdb
PDB entry 2vr3 coloured by chain, front view.
PDB entry 2vr3 coloured by chain, side view.
PDB entry 2vr3 coloured by chain, top view.
Source organisms:
Primary publication:
A structural model of the Staphylococcus aureus ClfA-fibrinogen interaction opens new avenues for the design of anti-staphylococcal therapeutics.
Ganesh VK, Rivera JJ, Smeds E, Ko YP, Bowden MG, Wann ER, Gurusiddappa S, Fitzgerald JR, Höök M
PLoS Pathog 4 e1000226 (2008)
PMID: 19043557

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136043 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Clumping factor A Chains: A, B
Molecule details ›
Chains: A, B
Length: 329 amino acids
Theoretical weight: 35.8 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2G015 (Residues: 228-545; Coverage: 36%)
Gene names: SAOUHSC_00812, clfA
Sequence domains:
Structure domains:
Fibrinogen gamma chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02679 (Residues: 425-433; Coverage: 2%)
Gene names: FGG, PRO2061

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 35.427Å b: 61.836Å c: 81.777Å
α: 85.44° β: 81.84° γ: 82.45°
R-values:
R R work R free
0.213 0.211 0.279
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

23 review citations

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus.
Foster et al. (2014)
22 more

10 mentions without citation

Structural biology of Gram-positive bacterial adhesins.
Vengadesan et al. (2011)
9 more