› 2vsc

X-ray diffraction
1.9Å resolution

Structure of the immunoglobulin-superfamily ectodomain of human CD47

Released:
DOI: 10.2210/pdb2vsc/pdb
PDB entry 2vsc coloured by chain, front view.
PDB entry 2vsc coloured by chain, side view.
PDB entry 2vsc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Hatherley D, Graham SC, Turner J, Harlos K, Stuart DI, Barclay AN
Mol Cell 31 266-77 (2008)
PMID: 18657508

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocyte surface antigen CD47 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q08722 (Residues: 19-136; Coverage: 39%)
Gene names: CD47, MER6
Sequence domains: CD47 immunoglobulin-like domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand NAG 12 x NAG
Ligand MG 2 x MG
1 modified residue:
Ligand PCA 4 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 201.137Å b: 47.502Å c: 56.811Å
α: 90° β: 99.31° γ: 90°
R-values:
R R work R free
0.219 0.216 0.263
Expression system: Cricetulus griseus

Quick links

Citations

37 review citations

The interaction between signal regulatory protein alpha (SIRPĪ±) and CD47: structure, function, and therapeutic target.
Barclay et al. (2014)
36 more

3 mentions without citation

The landscape overview of CD47-based immunotherapy for hematological malignancies.
Yang et al. (2023)
2 more