2w0p

X-ray diffraction
1.9Å resolution

Crystal structure of the filamin A repeat 21 complexed with the migfilin peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-149208 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Filamin-A Chains: A, B
Molecule details ›
Chains: A, B
Length: 94 amino acids
Theoretical weight: 9.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P21333 (Residues: 2236-2329; Coverage: 4%)
Gene names: FLN, FLN1, FLNA
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins
Filamin-binding LIM protein 1 Chain: C
Molecule details ›
Chain: C
Length: 15 amino acids
Theoretical weight: 1.62 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8WUP2 (Residues: 5-19; Coverage: 4%)
Gene names: FBLIM1, FBLP1

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 36.89Å b: 68.48Å c: 85.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.239
Expression systems:
  • Escherichia coli BL21
  • Not provided