› 2w2n

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134047 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 33.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-451; Coverage: 45%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Subtilase family
Structure domains: Peptidase S8/S53 domain
Low-density lipoprotein receptor Chain: E
Molecule details ›
Chain: E
Length: 107 amino acids
Theoretical weight: 12.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01130 (Residues: 314-393; Coverage: 10%)
Gene name: LDLR
Structure domains: Laminin
Proprotein convertase subtilisin/kexin type 9 Chain: P
Molecule details ›
Chain: P
Length: 114 amino acids
Theoretical weight: 12.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NBP7 (Residues: 53-152; Coverage: 15%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P43212
Unit cell:
a: 83.94Å b: 83.94Å c: 209.933Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.213 0.254
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

The PCSK9 decade.
Lambert et al. (2012)
20 more

4 mentions without citation

Crystal structures of the Arabidopsis thaliana organellar RNA editing factors MORF1 and MORF9.
Haag et al. (2017)
3 more