› 2w2t

X-ray diffraction
1.95Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related C3 botulinum toxin substrate 2 Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 20.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P15153 (Residues: 2-179; Coverage: 93%)
Gene name: RAC2
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 42.205Å b: 98.106Å c: 108.064Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.207 0.254
Expression system: Spodoptera frugiperda

Quick links

Citations

16 review citations

Phosphoinositides: tiny lipids with giant impact on cell regulation.
Balla T. (2013)
15 more

5 mentions without citation

Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.
Olson MF. (2018)
4 more