2w44

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134235 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 17 amino acids
Theoretical weight: 1.99 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 94-110; Coverage: 20%)
Gene name: INS
Insulin B chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 29 amino acids
Theoretical weight: 3.33 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P01308 (Residues: 25-53; Coverage: 34%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: C2221
Unit cell:
a: 41.05Å b: 88.62Å c: 73.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.258
Expression system: Saccharomyces cerevisiae