› 2w4l

X-ray diffraction
2.1Å resolution

Human dCMP deaminase

Released:
DOI: 10.2210/pdb2w4l/pdb
PDB entry 2w4l coloured by chain, front view.
PDB entry 2w4l coloured by chain, side view.
PDB entry 2w4l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Siponen MI, Moche M, Arrowsmith CH, Berglund H, Bountra C, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Karlberg T, Kotenyova T, Lehtio L, Nilsson ME, Nyman T, Persson C, Sagemark J, Schuler H, Thorsell AG, Tresaugues L, Van Den Berg S, Weigelt J, Welin M, Wikstrom M, Wisniewska M, Nordlund P

Function and Biology Details

Reaction catalysed: 
dCMP + H(2)O = dUMP + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152257 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxycytidylate deaminase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 178 amino acids
Theoretical weight: 20.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P32321 (Residues: 4-174; Coverage: 96%)
Gene name: DCTD
Sequence domains: Cytidine and deoxycytidylate deaminase zinc-binding region
Structure domains: Cytidine Deaminase, domain 2

Ligands and Environments

2 bound ligands:
Ligand ZN 6 x ZN
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21
Unit cell:
a: 66.23Å b: 80.07Å c: 96.24Å
α: 90° β: 94.34° γ: 90°
R-values:
R R work R free
0.202 0.2 0.243
Expression system: Escherichia coli BL21(DE3)

Quick links