› 2w65

X-ray diffraction
2.21Å resolution

Anti citrullinated Collagen type 2 antibody acc4 in complex with a citrullinated peptide

Released:
DOI: 10.2210/pdb2w65/pdb
PDB entry 2w65 coloured by chain, front view.
PDB entry 2w65 coloured by chain, side view.
PDB entry 2w65 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engström A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R
J Exp Med 206 449-62 (2009)
PMID: 19204106

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211607 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4 Chains: A, C
Molecule details ›
Chains: A, C
Length: 218 amino acids
Theoretical weight: 23.48 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4 Chains: B, D
Molecule details ›
Chains: B, D
Length: 217 amino acids
Theoretical weight: 23.92 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
COLLAGEN DERIVED PEPTIDE PCII-CIT1 Chains: E, F
Molecule details ›
Chains: E, F
Length: 9 amino acids
Theoretical weight: 902 Da
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
2 modified residues:
Ligand CIR 2 x CIR
Ligand HYP 2 x HYP

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-5
Spacegroup: P21
Unit cell:
a: 57.2Å b: 127.8Å c: 71.9Å
α: 90° β: 106° γ: 90°
R-values:
R R work R free
0.237 0.234 0.285
Expression system: Not provided

Quick links

Citations

55 review citations

Rheumatoid arthritis.
Scott et al. (2010)
54 more

3 mentions without citation

Epitope Specificity of Anti-Citrullinated Protein Antibodies.
Trier et al. (2017)
2 more