› 2w7x

X-ray diffraction
2.07Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase Chk2 Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 36.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O96017 (Residues: 209-531; Coverage: 60%)
Gene names: CDS1, CHEK2, CHK2, RAD53
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand D1A 1 x D1A
Ligand MG 1 x MG
Ligand NO3 1 x NO3
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3221
Unit cell:
a: 90.866Å b: 90.866Å c: 93.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.193 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

DNA repair dysregulation from cancer driver to therapeutic target.
Curtin NJ. (2012)
20 more

7 mentions without citation

Structure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapies.
Matthews et al. (2013)
6 more