› 2w9d

X-ray diffraction
1.57Å resolution

Structure of Fab fragment of the ICSM 18 - anti-Prp therapeutic antibody at 1.57 A resolution.

Released:
DOI: 10.2210/pdb2w9d/pdb
PDB entry 2w9d coloured by chain, front view.
PDB entry 2w9d coloured by chain, side view.
PDB entry 2w9d coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of human prion protein bound to a therapeutic antibody.
Antonyuk SV, Trevitt CR, Strange RW, Jackson GS, Sangar D, Batchelor M, Cooper S, Fraser C, Jones S, Georgiou T, Khalili-Shirazi A, Clarke AR, Hasnain SS, Collinge J
Proc Natl Acad Sci U S A 106 2554-8 (2009)
PMID: 19204296

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213187 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 215 amino acids
Theoretical weight: 23.24 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.3 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P212121
Unit cell:
a: 36.784Å b: 84.71Å c: 127.852Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.184 0.217

Quick links

Citations

12 review citations

Prions.
Colby et al. (2011)
11 more

5 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
4 more