› 2wah

X-ray diffraction
2.51Å resolution

Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2)

Released:
DOI: 10.2210/pdb2wah/pdb
PDB entry 2wah coloured by chain, front view.
PDB entry 2wah coloured by chain, side view.
PDB entry 2wah coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions.
Crispin M, Bowden TA, Coles CH, Harlos K, Aricescu AR, Harvey DJ, Stuart DI, Jones EY
J Mol Biol 387 1061-6 (2009)
PMID: 19236877

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 23.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 120-328; Coverage: 52%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 49.391Å b: 74.977Å c: 149.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.216 0.268
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Emerging principles for the therapeutic exploitation of glycosylation.
Dalziel et al. (2014)
8 more

24 mentions without citation

Function and 3D structure of the N-glycans on glycoproteins.
Nagae et al. (2012)
23 more