› 2wce

X-ray diffraction
1.77Å resolution

calcium-free (apo) S100A12

Released:
DOI: 10.2210/pdb2wce/pdb
PDB entry 2wce coloured by chain, front view.
PDB entry 2wce coloured by chain, side view.
PDB entry 2wce coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structures of human S100A12 in apo form and in complex with zinc: new insights into S100A12 oligomerisation.
Moroz OV, Blagova EV, Wilkinson AJ, Wilson KS, Bronstein IB
J Mol Biol 391 536-51 (2009)
PMID: 19501594

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A12 Chains: A, B
Molecule details ›
Chains: A, B
Length: 95 amino acids
Theoretical weight: 10.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P80511 (Residues: 2-92; Coverage: 99%)
Gene name: S100A12
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: R3
Unit cell:
a: 77.516Å b: 77.516Å c: 99.076Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.165 0.163 0.205
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Functions of S100 proteins.
Donato et al. (2013)
15 more

9 mentions without citation

Going deep into protein secondary structure with synchrotron radiation circular dichroism spectroscopy.
Kumagai et al. (2017)
8 more