› 2wcy

Solution NMR

NMR solution structure of factor I-like modules of complement C7.

Released:
DOI: 10.2210/pdb2wcy/pdb
PDB entry 2wcy coloured by chain, ensemble of 48 models, front view.
PDB entry 2wcy coloured by chain, ensemble of 48 models, side view.
PDB entry 2wcy coloured by chain, ensemble of 48 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.
Phelan MM, Thai CT, Soares DC, Ogata RT, Barlow PN, Bramham J
J Biol Chem 284 19637-49 (2009)
PMID: 19419965

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145407 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement component C7 Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 16.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10643 (Residues: 693-843; Coverage: 18%)
Gene name: C7
Sequence domains:
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: SIMULATED ANNEAILING, RESTRAINED MOLECULAR DYNAMICS
Expression system: Escherichia coli

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Citations

1 review citation

Putting the structure into complement.
Lea et al. (2012)
2 other articles

8 mentions without citation

Structural basis of complement membrane attack complex formation.
Serna et al. (2016)
7 more