› 2wdp

X-ray diffraction
1.95Å resolution

Crystal Structure of Ligand Free Human Caspase-6

Released:
DOI: 10.2210/pdb2wdp/pdb
PDB entry 2wdp coloured by chain, front view.
PDB entry 2wdp coloured by chain, side view.
PDB entry 2wdp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of caspase-6, a selective effector of axonal degeneration.
Baumgartner R, Meder G, Briand C, Decock A, D'arcy A, Hassiepen U, Morse R, Renatus M
Biochem J 423 429-39 (2009)
PMID: 19694615

Function and Biology Details

Reaction catalysed: 
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157270 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase-6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 293 amino acids
Theoretical weight: 33.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55212 (Residues: 1-293; Coverage: 100%)
Gene names: CASP6, MCH2
Sequence domains: Caspase domain
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 63.146Å b: 90.441Å c: 86.397Å
α: 90° β: 92.77° γ: 90°
R-values:
R R work R free
0.226 0.224 0.262
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Huntington's disease: from molecular pathogenesis to clinical treatment.
Ross et al. (2011)
4 more

14 mentions without citation

Small Molecule Active Site Directed Tools for Studying Human Caspases.
Poreba et al. (2015)
13 more