› 2wfh

X-ray diffraction
1.8Å resolution

The Human Slit 2 Dimerization Domain D4

Released:
DOI: 10.2210/pdb2wfh/pdb
PDB entry 2wfh coloured by chain, front view.
PDB entry 2wfh coloured by chain, side view.
PDB entry 2wfh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and functional relevance of the Slit2 homodimerization domain.
Seiradake E, von Philipsborn AC, Henry M, Fritz M, Lortat-Jacob H, Jamin M, Hemrika W, Bastmeyer M, Cusack S, McCarthy AA
EMBO Rep 10 736-41 (2009)
PMID: 19498462

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131764 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Slit homolog 2 protein N-product Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 21.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94813 (Residues: 725-907; Coverage: 12%)
Gene names: SLIL3, SLIT2
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: I41
Unit cell:
a: 128.66Å b: 128.66Å c: 48.15Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.219
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Extracellular matrix: functions in the nervous system.
Barros et al. (2011)
9 more

7 mentions without citation

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.
McEwan et al. (2011)
6 more