› 2wh5

X-ray diffraction
2.6Å resolution

Crystal structure of human acyl-CoA binding domain 4 complexed with stearoyl-CoA

Released:
DOI: 10.2210/pdb2wh5/pdb
PDB entry 2wh5 coloured by chain, front view.
PDB entry 2wh5 coloured by chain, side view.
PDB entry 2wh5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yue WW, Shafqat N, Ugochukwu E, Savitsky P, Johansson C, Salah E, Roos AK, Chaikuad A, von Delft F, Arrowsmith C, Weigelt J, Edwards A, Bountra C, Oppermann U

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185483 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-CoA-binding domain-containing protein 4 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 106 amino acids
Theoretical weight: 12.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NC06 (Residues: 7-110; Coverage: 39%)
Gene names: ACBD4, HMFT0700
Sequence domains: Acyl CoA binding protein
Structure domains: Acyl-CoA Binding Protein

Ligands and Environments

3 bound ligands:
Ligand STE 6 x STE
Ligand ST9 6 x ST9
Ligand COA 2 x COA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 85.06Å b: 95.1Å c: 119.74Å
α: 90° β: 110.28° γ: 90°
R-values:
R R work R free
0.207 0.206 0.236
Expression system: Escherichia coli BL21(DE3)

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