› 2wjw

X-ray diffraction
1.8Å resolution

Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 1.8 A resolution

Released:
DOI: 10.2210/pdb2wjw/pdb
PDB entry 2wjw coloured by chain, front view.
PDB entry 2wjw coloured by chain, side view.
PDB entry 2wjw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.
Clayton A, Siebold C, Gilbert RJ, Sutton GC, Harlos K, McIlhinney RA, Jones EY, Aricescu AR
J Mol Biol 392 1125-32 (2009)
PMID: 19651138

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154589 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 43.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42262 (Residues: 25-412; Coverage: 45%)
Gene names: GLUR2, GRIA2, GluA2
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

4 bound ligands:
Ligand NAG 1 x NAG
Ligand CL 1 x CL
Ligand SO4 1 x SO4
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: I222
Unit cell:
a: 50.977Å b: 122.455Å c: 138.852Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.217
Expression system: Homo sapiens

Quick links

Citations

17 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
16 more

5 mentions without citation

Emerging models of glutamate receptor ion channel structure and function.
Mayer ML. (2011)
4 more