› 2wl1

X-ray diffraction
1.35Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyrin Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15553 (Residues: 586-776; Coverage: 25%)
Gene names: MEF, MEFV, TRIM20
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand SCN 2 x SCN
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P6522
Unit cell:
a: 60.27Å b: 60.27Å c: 182.03Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.193 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.
Grütter et al. (2012)
7 more

17 mentions without citation

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.
D'Cruz et al. (2013)
16 more