› 2wqj

X-ray diffraction
2Å resolution

Crystal structure of a truncated variant of the human p73 tetramerization domain

Released:
DOI: 10.2210/pdb2wqj/pdb
PDB entry 2wqj coloured by chain, front view.
PDB entry 2wqj coloured by chain, side view.
PDB entry 2wqj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural evolution of p53, p63, and p73: implication for heterotetramer formation.
Joerger AC, Rajagopalan S, Natan E, Veprintsev DB, Robinson CV, Fersht AR
Proc Natl Acad Sci U S A 106 17705-10 (2009)
PMID: 19815500

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo hexamer
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127444 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor protein p73 Chains: 1, 2, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z
Molecule details ›
Chains: 1, 2, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z
Length: 35 amino acids
Theoretical weight: 4.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15350 (Residues: 350-383; Coverage: 5%)
Gene names: P73, TP73
Sequence domains: P53 tetramerisation motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 57.85Å b: 98.93Å c: 120.12Å
α: 90° β: 91.77° γ: 90°
R-values:
R R work R free
0.212 0.21 0.248
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Translating p53 into the clinic.
Cheok et al. (2011)
26 more

5 mentions without citation

Structure and apoptotic function of p73.
Yoon et al. (2015)
4 more