› 2wxw

X-ray diffraction
3.3Å resolution

Crystal structure of human angiotensinogen

Released:
DOI: 10.2210/pdb2wxw/pdb
PDB entry 2wxw coloured by chain, front view.
PDB entry 2wxw coloured by chain, side view.
PDB entry 2wxw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A redox switch in angiotensinogen modulates angiotensin release.
Zhou A, Carrell RW, Murphy MP, Wei Z, Yan Y, Stanley PL, Stein PE, Broughton Pipkin F, Read RJ
Nature 468 108-11 (2010)
PMID: 20927107

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiotensinogen Chain: A
Molecule details ›
Chain: A
Length: 453 amino acids
Theoretical weight: 49.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01019 (Residues: 25-476; Coverage: 100%)
Gene names: AGT, SERPINA8
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P41212
Unit cell:
a: 133.285Å b: 133.285Å c: 123.602Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.31 0.309 0.318
Expression system: Escherichia coli BL21(DE3)

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Citations

37 review citations

Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease.
Powe et al. (2011)
36 more

15 mentions without citation

Control of blood proteins by functional disulfide bonds.
Butera et al. (2014)
14 more