› 2x44

X-ray diffraction
2.6Å resolution

Structure of a strand-swapped dimeric form of CTLA-4

Released:
DOI: 10.2210/pdb2x44/pdb
PDB entry 2x44 coloured by chain, front view.
PDB entry 2x44 coloured by chain, side view.
PDB entry 2x44 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Domain metastability: a molecular basis for immunoglobulin deposition?
Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ
J Mol Biol 399 207-13 (2010)
PMID: 20394753

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxic T-lymphocyte protein 4 Chain: D
Molecule details ›
Chain: D
Length: 131 amino acids
Theoretical weight: 14.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16410 (Residues: 36-163; Coverage: 68%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 42.951Å b: 42.951Å c: 140.101Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.192 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Considering B7-CD28 as a family through sequence and structure.
West et al. (2019)
12 other articles

1 mention without citation

Domain metastability: a molecular basis for immunoglobulin deposition?
Sonnen et al. (2010)