› 2x4d

X-ray diffraction
1.92Å resolution

Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP

Released:
DOI: 10.2210/pdb2x4d/pdb
PDB entry 2x4d coloured by chain, front view.
PDB entry 2x4d coloured by chain, side view.
PDB entry 2x4d coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Vollmar M, Gileadi C, Guo K, Savitsky P, Muniz JRC, Yue W, Allerston C, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Kavanagh KL, Oppermann U

Function and Biology Details

Reaction catalysed: 
Diphosphate + H(2)O = 2 phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190466 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 29.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H008 (Residues: 1-270; Coverage: 100%)
Gene name: LHPP
Sequence domains:
Structure domains: HAD superfamily/HAD-like

Ligands and Environments

4 bound ligands:
Ligand POP 2 x POP
Ligand MG 2 x MG
Ligand EPE 2 x EPE
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 59.21Å b: 39.41Å c: 112.92Å
α: 90° β: 91.79° γ: 90°
R-values:
R R work R free
0.229 0.227 0.258
Expression system: Escherichia coli BL21(DE3)

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